Autoimmune diseases affect between 5-10 percent of the U.S. population, with 80 percent of those affected being female. These conditions tend to peak during a woman’s reproductive years, making their occurrence in pregnancy relatively common.
Like most people, pregnant women with healthy immune systems produce antibodies that identify and attack foreign substances that enter their bodies, such as bacteria and viruses, to protect them from getting sick. In those with autoimmune diseases, however, their immune systems mistakenly attack the healthy cells in their bodies as well.
In many cases, yes. But there are a number of things you should do BEFORE getting pregnant to help ensure a healthy pregnancy for you and your baby. Because of this, it’s important to schedule an appointment with an experienced OB-GYN if you’re thinking about having a baby.
It’s also important to know that pregnancy can trigger an autoimmune disease. However, some symptoms of preexisting autoimmune diseases actually lessen during pregnancy.
The risks associated with having an autoimmune disease during pregnancy vary depending on which autoimmune disease you have, but some of the most common risks include:
Below is a list of some of the most common autoimmune diseases, along with their associated pregnancy risks and treatments.
APS is a rare autoimmune disease in which antibodies mistakenly attack a type of fat, called phospholipids, and proteins that line the blood vessels, putting mothers at an increased risk of blood clots and pulmonary embolisms during pregnancy.
APS also increases the risk of:
Treatment for APS during pregnancy includes medications to help prevent blood clots, such as low-dose aspirin, as well as other anticoagulants, like heparin.
Scleroderma is an autoimmune disease that commonly affects the skin and other bodily organs. It causes inflammation in the body, which can make the skin feel stiff and tight and cause scarring on various organs, leading to high blood pressure as well as nerve, muscle, joint, lung and kidney issues.
Scleroderma increases the risk of:
Treatment for scleroderma during pregnancy includes medication adjustments and more frequent prenatal care to monitor you and your baby and prevent/treat issues such as high blood pressure and organ damage or failure.
SLE, commonly known as lupus, is one of the higher-risk autoimmune diseases during pregnancy in which a woman’s immune system attacks healthy tissue within her body and causes inflammation. Lupus can affect a wide range of areas in the body, including the vascular system, brain, lungs, kidneys, joints and skin. Symptoms may include fatigue, joint pain, fever and rashes.
Lupus increases the risk of:
Treatment for lupus during pregnancy includes medication monitoring/adjustments to control your symptoms as well as more frequent prenatal care and monitoring. So, make sure you attend all of your scheduled OB-GYN appointments.
Despite the risks, women with lupus often have good pregnancy outcomes if they can achieve remission before getting pregnant.
Sjogren’s syndrome is an autoimmune disease that attacks moisture-producing glands in the body, in areas such as the eyes and mouth, leading to issues like a painful, burning sensation in the eyes, dry mouth, swollen neck glands and vaginal dryness. If it progresses, Sjogren’s syndrome can also damage the kidneys, lungs, thyroid, liver and nervous system.
Sjogren’s syndrome increases the risk of:
Treatment for Sjogren’s syndrome during pregnancy includes close monitoring of the fetus’s heart with frequent echocardiograms (ultrasounds that show detailed images of the heart).
ITP is an autoimmune disease that causes a decrease in the number of platelets in the blood, which can lead to excessive bleeding in the mother as well as the fetus. Unfortunately, this condition tends to get worse during pregnancy.
Treatment for ITP during pregnancy includes steroid medications, such as prednisone, to increase platelets. However, prednisone has only been shown to be effective in about 50 percent of pregnant women and may put the fetus at an increased risk for certain complications.
Your OB-GYN may administer a medication called immune globulin immediately before a vaginal delivery to reduce your risk of bleeding during delivery.
Rheumatoid arthritis is an autoimmune disease that causes inflammation in the joints, resulting in pain, stiffness and swelling.
The good news is that RA does not affect the fetus, and in about 50 percent of mothers, symptoms of RA become less severe during pregnancy. Some RA medications are unsafe to take during pregnancy, so medication changes and adjustments may be needed before conception.
Studies have shown that achieving remission from an autoimmune disease for 6 months prior to pregnancy reduces the risk of complications for both mothers and babies. Your doctor may need to adjust your medications to accomplish this goal.
This is one reason why it’s essential to talk with a qualified OB-GYN before you get pregnant if you have an autoimmune disease. In addition to helping you get into remission, your doctor may also need to adjust your medications to ensure the medications and doses you’re taking are safe during pregnancy.
Other ways to help keep you and your baby healthy include: